Publications

Randomized, Placebo-controlled Prospective Clinical Trial Evaluating the Efficacy of the Assisi Anti-anxiety Device (Calmer Canine) for the Treatment of Canine Separation Anxiety

Pankratz, K., Korman, J., Emke, C., Johnson, B., Griffith, E. H., & Gruen, M. E. (2021). Frontiers in Veterinary Science, 8, 1-10.

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A Literature Review: Pet Bereavement and Coping Mechanisms

Park, R. M., Royal, K. D., & Gruen, M. E. (2021). Journal of Applied Animal Welfare Science, 24(2), 1-16.

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Evaluation of Pexion® (Imepitoin) for Treatment of Storm Anxiety in Dogs: A Randomised, Double-blind, Placebo-controlled Trial

Perdew, I., Emke, C., Johnson, B., Dixit, V., Song, Y., Griffith, E. H., . . . Gruen, M. E. (2021). The Veterinary Record, 188(9), e18.

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Association Between Dog Owner Demographics and Decision to Seek Veterinary Care

Park, R. M., Gruen, M. E., & Royal, K. (2021). Veterinary Sciences, 8 (1), 1-19.

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Evaluation of Repeated Dosing of a Dexmedetomidine Oromucosal Gel for Treatment of Noise Aversion in Dogs Over a Series of Noise Events

Gruen, M., Case, B. C., Robertson, J. B., Campbell, S., & Korpivaara, M. E. (2020). Veterinary Record, 187(12), 489-495.

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A Systematic Literature Review of Animal-Assisted Interventions in Oncology (Part I): Methods and Results

Holder, T. R. N., Gruen, M. E., Roberts, D. L., Somers, T., & Bozkurt, A. (2020). Integrative Cancer Therapies, 19, 1-19.

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A Systematic Literature Review of Animal-Assisted Interventions in Oncology (Part II): Theoretical Mechanisms and Frameworks

Holder, T. R. N., Gruen, M. E., Roberts, D. L., Somers, T., & Bozkurt, A. (2020). Integrative Cancer Therapies, 19, 1-18.

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Preliminary Evaluation of a Wearable Sensor System for Heart Rate Assessment in Guide Dog Puppies

Foster, M., Brugarolas, R., Walker, K., Mealin, S., Cleghern, Z., Yuschak, S., . . . Bozkurt, A. (2020). IEEE Sensors Journal, 20(16), 9449-9459.

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Effect of Wearing a Telemetry Jacket on Behavioral and Physiologic Parameters of Dogs in the Open-field Test

Fish, R. E., Foster, M. L., Gruen, M. E., Sherman, B. L., & Dorman, D. C. (2017).. Journal of the American Association for Laboratory Animal Science, 56(4), 382-389.

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A Test for the Evaluation of Emotional Reactivity in Labrador Retrievers Used for Explosives Detection

Sherman, B. L., Gruen, M. E., Case, B. C., Foster, M. L., Fish, R. E., Lazarowski, L., . . . Dorman, D. C. (2015). Journal of Veterinary Behavior, 10(2), 94-102.

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The Use of an Open-field Model to Assess Sound-induced Fear and Anxiety-associated Behaviors in Labrador Retrievers

Gruen, M. E., Case, B. C., Foster, M. L., Lazarowski, L., Fish, R. E., Landsberg, G., . . . Sherman, B. L. (2015). Journal of Veterinary Behavior, 10(4), 338-345.

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Cooperative Communication with Humans Evolved to Emerge Early in Domestic Dogs

Salomons, H., Smith, K. C. M., Callahan-Beckel, M., Callahan, M., Levy, K., Kennedy, B. S., . . . Hare, B. (2021). Current Biology, 31(14), 3137-3144.

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Dog Cognitive Development: A Longitudinal Study Across the First 2 Years of Life

Bray, E. E., Gruen, M. E., Gnanadesikan, G. E., Horschler, D. J., Levy, K. M., Kennedy, B. S., . . . MacLean, E. L. (2021). Animal Cognition, 24(2), 311-328.

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A Brief Report of Sleep and Circadian Rhythm Quotas in a Population of Dog Owners in North Carolina, USA

Patel, U. A., Gruen, M. E., & Samson, D. R. (2021). bioRxiv, 1-14.

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Cognitive Characteristics of 8- to 10-week-old Assistance Dog Puppies

Bray, E. E., Gruen, M. E., Gnanadesikan, G. E., Horschler, D. J., Levy, K. M., Kennedy, B. S., . . . MacLean, E. L. (2020). Animal Behaviour, 166, 193-206.

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A Functional Linear Modeling Approach to Sleep-wake Cycles in Dogs

Woods, H. J., Li, M. F., Patel, U. A., Lascelles, B. D. X., Sampson, D. R., & Gruen, M. G. (2020). Scientific Reports, 10, 1-8.

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Does the Cognitive Bias Test in Dogs Depend on Spatial Learning

Gruen, M. E., Foster, M. L., Lazarowski, L., Jeffries, A., Sherman, B. L., & Dorman, D. C. (2019). Journal of Veterinary Behavior, 33, 1-6.

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Acquisition of a Visual Discrimination and Reversal Learning Task by Labrador Retrievers

Lazarowski, L., Foster, M. L., Gruen, M. E., Sherman, B. L., Case, B. C., Fish, R. E., . . . Dorman, D. C. (2014). Animal Cognition, 17(3), 787-792.

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Activity Patterns are Associated with Fractional Lifespan, Memory, and Gait Speed in Aged Dogs

Mondino A, Khan M, Case B, Giovagnoli S, Thomson A, Lascelles BDX, Gruen ME, Olby N. (2023). Nature Scientific Reports, 13

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Relationship Between Engagement with the Impossible Task, Cognitive Testing, and Cognitive Questionnaires in a Population of Aging Dogs

Khan MZ, Mondino A, Russell K, Case B, Fefer G, Woods H, Olby N, Gruen ME. (2023). Frontiers in Veterinary Science

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Use of Cognitive Testing, Questionnaires and Plasma Biomarkers to Quantify Cognitive Impairment in an Aging Pet Dog Population

Fefer G, Panek WK, Khan MZ, Singer M, Westermeyer H, Mowat FM, Murdoch DM, Case B, Olby NJ*, Gruen ME*. (2022). Journal of Alzheimers Disease, Jan. 2022:1367 – 1378.

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Relationship Between Hearing, Cognitive Function, and Quality of Life in Aging Companion Dogs

Fefer G, Khan MZ, Panek WK, Case B, Gruen ME*, Olby NJ*. (2022). Journal of Veterinary Internal Medicine, 36 (5), 1708-1718.

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Static Posturography as a Novel Measure of the Effects of Aging on Postural Control in Dogs

Mondino A., Wagner G., Russell K., Lobaton E., Griffith E, Gruen, M., . . . Olby, N. J. (2022). PLoS ONE, 17(7), 1-20.

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Use of Cognitive Testing, Questionnaires, and Plasma Biomarkers to Quantify Cognitive Impairment in an Aging Pet Dog Population

Fefer, G., Panek, W. K., Khan, M. Z., Singer, M., Westermeyer, H. D., Mowat, F. M., . . . Gruen, M. E. (2022). Journal of Alzheimer’s Disease, 87(3), 1367-1378.

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Canine Geriatric Syndrome: A Framework for Advancing Research in Veterinary Geroscience

McKenzie, B. A., Chen, F. L., Gruen, M. E., & Olby, N. J. (2022). Frontiers in Veterinary Science, 9, 1-13.

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Age-related Visual Decline in Companion Dogs: A Cross-sectional ERG Study in a Translational Model Species

Mowat, F. M., Panek, W. K., Fefer, G., Banghart, M., Wagner, G., Westermeyer, H. D., . . . Olby, N. (2021). Investigative Ophthalmology & Visual Science, 62(8), 500.

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Plasma Amyloid Beta Concentrations in Aged and Cognitively Impaired Pet Dogs

Panek, W. K., Murdoch, D. M., Gruen, M. E., Mowat, F. M., Marek, R. D., & Olby, N. J. (2021). Molecular Neurobiology, 58(2), 483-489.

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Sustained Gaze is a Reliable In-home Test of Attention for Aging Pet Dogs

Hoel, J. A., Templeton, G. B., Fefer, G., Case, B. C., Shah, A., Gruen, M. E., & Olby, N. J. (2021). Frontiers in Veterinary Science, 8, 1-9.

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Plasma Neurofilament Light Chain as a Translational Biomarker of Aging and Neurodegeneration in Dogs

Panek, W. K., Gruen, M. E., Murdoch, D. M., Marek, R. D., Statchel, A. F., Mowat, F. M., . . . Olby, N. J. (2020). Molecular Neurobiology, 57(7), 3143-3149.

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A Novel Test of Canine Olfaction for Use in Adult and Senior Pet Dogs

Khan MZ, Mondino A, Russell K, Case B, Fefer G, Woods H, Olby N, Gruen ME. (2023). Nature Scientific Reports

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Olfactory Discrimination and Generalization of Ammonium Nitrate and Structurally Related Odorants in Labrador Retrievers

Lazarowski, L., Foster, M. L., Gruen, M. E., Sherman, B. L., Fish, R. E, Milgram, N. W., & Dorman, D. C. (2015). Animal Cognition, 18(6), 1255-1265.

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2022 AAHA Pain Management Guidelines for Dogs and Cats

Gruen, M. E., Lascelles, B. D. X., Colleran, E., Gottlieb, A., Johnson, J., Lotsikas, P., . . . Wright, B. (2022). Journal of the American Animal Hospital Association, 58(2), 55-76.

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Assessment of Sensory Thresholds in Dogs Using Mechanical and Hot Thermal Quantitative Sensory Testing

Cunningham, R. M., Park, R. M., Knazovicky, D., Lascelles, B. D. X., & Gruen, M. E. (2021). Journal of Visualized Experiments, 176(e62841), 1-17.

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Do Dog Breeds Differ in Pain Sensitivity? Veterinarians and the Public Believe They Do

Gruen, M. E., White, W., & Hare, B. (2020). PLoS ONE, 15(3), 1-14.

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Functional Linear Modeling of Activity Data Shows Analgesic-mediated Improved Sleep in Dogs with Spontaneous Osteoarthritis Pain

Gruen, M. E., Samson, D. R., & Lascelles, B. D. X. (2019). Scientific Reports, 9(14192), 1-6.

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Replicate Effects and Test-Retest Reliability of Quantitative Sensory Threshold Testing in Dogs With and Without Chronic Pain

Knazovixky, D., Helgeson, E. S., Case, B., Thomson, A., Gruen, M. E., Maixner, W., & Lascelles, B. D. X. (2018). Veterinary and Comparative Orthopaedics and Traumatology, 31(S 01).

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The Use of Trazodone to Facilitate Calm Behavior After Elective Orthopedic Surgery in Dogs: Results and Lessons Learned from a Clinical Trial

Gruen, M. E., Roe, S. C., Griffith, E. H., & Sherman, B. L. (2017). Journal of Veterinary Behavior, 22, 41-45.

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Use of Trazadone to Facilitate Postsurgical Confinement in Dogs

Gruen, M. E., Roe, S. C., Griffist, E., Hamilton, A., & Sherman, B. L. (2014). Journal of the American Veterinary Medical Association, 245(3), 296-301.

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Enrichment Preferences of FIV-infected and Uninfected Laboratory-housed Cats

Kennedy, C. J., Thomson, A. E., Griffith, E. H., Fogle, J., Lascelles, B. D. X., Meeker, R. B., . . . Gruen, M. E. (2018). Viruses, 10(7), 1-10.

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Efficacy of a Single Dose of Trazodone Hydrochloride Given to Cats Prior to Veterinary Visits to Reduce Signs of Transport- and Examination-related Anxiety 

Stevens, B. J., Frantz, E. M., Orlando, J. M., Griffith, E., Harden, L. B., Gruen, M. E., & Sherman, B. L. (2016). Journal of the American Veterinary Medical Association, 249(2), 202-207.

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Conditioning Laboratory Cats to Handling and Transport

Gruen, M. E., Thomson, A. E., Clary, G. P., Hamilton, A. K., Hudson, L. C., Meeker, R. B., & Sherman, B. L. (2013). Lab Animal, 42, 385-389.

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Improved Neurocognitive Performance in FIV Infected Cats Following Treatment with the p75 Neurotrophin Receptor Ligand LM11A-31

Fogle, J. E., Hudson, L., Thomson, A., Sherman, B., Gruen, M, Lascelles, B. D., . . . Meeker, R. B. (2021). Journal of NeuroVirology, 27(2), 302-324.

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The Use of a T-maze to Measure Cognitive-motor Function in Cats (Felis catus)

Sherman, B. L., Gruen, M. E., Meeker, R. B., Milgram, B., DiRivera, C., Thomson, A., . . . Hudson, L. (2013). Journal of Veterinary Behavior, 8(1), 32-39.

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2022 AAHA Pain Management Guidelines for Dogs and Cats

Gruen, M. E., Lascelles, B. D. X., Colleran, E., Gottlieb, A., Johnson, J., Lotsikas, P., . . . Wright, B. (2022). Journal of the American Animal Hospital Association, 58(2), 55-76.

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Refinement of the Feline Musculoskeletal Pain Index (FMPI) and Development of the Short Term FMPI

Enomoto, M., Lascelles, B. D. X., & Gruen, M. E. (2022). Journal of Feline Medicine and Surgery, 24(2), 142-151.

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Evaluation of a Nutritional Supplement for the Alleviation of Pain Associated with Feline Degenerative Joint Disease: A Prospective, Randomized, Stratified, Double-blind, Placebo-controlled Clinical Trial

Cunningham, R., Gruen, M. E., Thomson, A., & Lascelles, B. D. X. (2021). Journal of Feline Medicine and Surgery, 1-13.

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Frunevetmab, a Felinized Anti-nerve Growth Factor Monoclonal Antibody, for the Treatment of Pain from Osteoarthritis in Cats

Gruen, M. E., Myers, J. A. E., Tena, J. S., Becskei C., Cleaver, D. M., & Lascelles, B. D. X. (2021). Journal of Veterinary Internal Medicine, 35, 2752-2762.

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Efficacy and Safety of an Anti-nerve Growth Factor Antibody (Frunevetmab) for the Treatment of Degenerative Joint Disease-associated Chronic Pain in Cats: A Multisite Pilot Field Study

Gruen, M. E., Myers, J. A. E., & Lascelles, B. D. X. (2021). Frontiers in Veterinary Science, 8, 1-13.

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Robenacoxib Shows Efficacy for the Treatment of Chronic Degenerative Joint Disease-associated Pain in Cats: A Randomized and Blinded Pilot Clinical Trial

Adrian, D., King, J. N., Parrish, R. S., King, S. B., Budsberg, S. C., Gruen, M. E., & Lascelles, B. D. X. (2021). Scientific Reports, 11(1), 1-14.

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Development of a Checklist for the Detection of Degenerative Joint Disease-associated Pain in Cats

Enomoto, M., Lascelles, B. D. X., & Gruen, M. E. (2020). Journal of Feline Medicine and Surgery, 22(12), 1137-1147.

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